| Round 1 (22) | Round 2 (23) |
| Deportivo - Milan | Aberdeen - Sporting |
| FC Augsburg - Rangers | Arsenal - Roma |
| FC Basel - VfB Stuttgart | Inter - FC Augsburg |
| FC Twente - Inter | Milan - Fenerbahçe |
| Fenerbahçe - Aberdeen | Newcastle United - Deportivo |
| Manchester United - Valencia | Paris SG - Sevilla |
| Real Betis - Spartak | RB Leipzig - FC Basel |
| Roma - RB Leipzig | Rangers - FC Twente |
| Sevilla - Arsenal | Spartak - Tottenham Hotspur |
| Sporting - Newcastle United | Valencia - Real Betis |
| Tottenham Hotspur - Paris SG | VfB Stuttgart - Manchester United |
|
| Round 3 (24) | Round 4 (25) |
| Deportivo - VfB Stuttgart | Aberdeen - FC Augsburg |
| FC Augsburg - Valencia | Arsenal - Real Betis |
| FC Basel - Arsenal | Inter - Sporting |
| FC Twente - Newcastle United | Milan - FC Basel |
| Fenerbahçe - Rangers | Newcastle United - Fenerbahçe |
| Manchester United - RB Leipzig | Paris SG - Manchester United |
| Real Betis - Aberdeen | RB Leipzig - Tottenham Hotspur |
| Roma - Paris SG | Rangers - Roma |
| Sevilla - Inter | Spartak - Deportivo |
| Sporting - Spartak | Valencia - FC Twente |
| Tottenham Hotspur - Milan | VfB Stuttgart - Sevilla |
|
| Round 5 (26) | Round 6 (27) |
| Deportivo - RB Leipzig | Arsenal - VfB Stuttgart |
| FC Augsburg - Milan | Deportivo - Manchester United |
| FC Basel - Inter | FC Augsburg - Sporting |
| FC Twente - Spartak | FC Basel - Roma |
| Fenerbahçe - Paris SG | Fenerbahçe - FC Twente |
| Manchester United - Arsenal | Newcastle United - Inter |
| Real Betis - VfB Stuttgart | RB Leipzig - Paris SG |
| Roma - Aberdeen | Sevilla - Rangers |
| Sevilla - Newcastle United | Spartak - Milan |
| Sporting - Valencia | Tottenham Hotspur - Real Betis |
| Tottenham Hotspur - Rangers | Valencia - Aberdeen |
|
| Round 7 (28) | Round 8 (29) |
| Aberdeen - Sevilla | Aberdeen - Milan |
| FC Twente - FC Augsburg | Arsenal - RB Leipzig |
| Inter - Spartak | FC Augsburg - Fenerbahçe |
| Manchester United - Tottenham Hotspur | FC Twente - Manchester United |
| Milan - Valencia | Inter - Rangers |
| Paris SG - Arsenal | Newcastle United - VfB Stuttgart |
| Rangers - Newcastle United | Paris SG - Sporting |
| Real Betis - FC Basel | Real Betis - Deportivo |
| Roma - Deportivo | Sevilla - Roma |
| Sporting - Fenerbahçe | Tottenham Hotspur - FC Basel |
| VfB Stuttgart - RB Leipzig | Valencia - Spartak |
|
| Round 9 (30) | Round 10 (31) |
| Deportivo - Tottenham Hotspur | Aberdeen - Paris SG |
| FC Basel - Sevilla | FC Augsburg - Real Betis |
| Fenerbahçe - Valencia | FC Twente - FC Basel |
| Manchester United - Real Betis | Fenerbahçe - Deportivo |
| Milan - Inter | Inter - RB Leipzig |
| RB Leipzig - Newcastle United | Milan - VfB Stuttgart |
| Rangers - Arsenal | Newcastle United - Arsenal |
| Roma - FC Augsburg | Rangers - Manchester United |
| Spartak - Aberdeen | Spartak - Roma |
| Sporting - FC Twente | Sporting - Tottenham Hotspur |
| VfB Stuttgart - Paris SG | Valencia - Sevilla |
|
| Round 11 (32) | Round 12 (33) |
| Arsenal - FC Augsburg | Arsenal - FC Twente |
| Deportivo - Sporting | Deportivo - FC Augsburg |
| FC Basel - Aberdeen | FC Basel - Rangers |
| Manchester United - Fenerbahçe | Manchester United - Sporting |
| Paris SG - Inter | Paris SG - Milan |
| RB Leipzig - Milan | RB Leipzig - Aberdeen |
| Real Betis - Rangers | Real Betis - Inter |
| Roma - Valencia | Roma - Newcastle United |
| Sevilla - FC Twente | Sevilla - Spartak |
| Tottenham Hotspur - Newcastle United | Tottenham Hotspur - Fenerbahçe |
| VfB Stuttgart - Spartak | VfB Stuttgart - Valencia |
|
| Round 13 (34) | Round 14 (35) |
| Aberdeen - VfB Stuttgart | Arsenal - Milan |
| FC Augsburg - Manchester United | Deportivo - Aberdeen |
| FC Twente - Tottenham Hotspur | FC Basel - Spartak |
| Fenerbahçe - FC Basel | Manchester United - Newcastle United |
| Inter - Deportivo | Paris SG - Valencia |
| Milan - Roma | RB Leipzig - Rangers |
| Newcastle United - Real Betis | Real Betis - Sporting |
| Rangers - Paris SG | Roma - Fenerbahçe |
| Spartak - Arsenal | Sevilla - FC Augsburg |
| Sporting - Sevilla | Tottenham Hotspur - Inter |
| Valencia - RB Leipzig | VfB Stuttgart - FC Twente |
|
| Round 15 (36) | Round 16 (37) |
| Aberdeen - Arsenal | Arsenal - Valencia |
| FC Augsburg - Tottenham Hotspur | Deportivo - Rangers |
| FC Twente - Deportivo | FC Basel - Newcastle United |
| Fenerbahçe - Real Betis | Manchester United - Milan |
| Inter - Manchester United | Paris SG - Spartak |
| Milan - Sevilla | RB Leipzig - FC Augsburg |
| Newcastle United - Paris SG | Real Betis - FC Twente |
| Rangers - VfB Stuttgart | Roma - Inter |
| Spartak - RB Leipzig | Sevilla - Fenerbahçe |
| Sporting - Roma | Tottenham Hotspur - Aberdeen |
| Valencia - FC Basel | VfB Stuttgart - Sporting |
|
| Round 17 (38) | Round 18 (39) |
| Deportivo - Arsenal | Deportivo - Sevilla |
| FC Augsburg - Newcastle United | FC Augsburg - FC Basel |
| FC Basel - Paris SG | FC Twente - Roma |
| FC Twente - Aberdeen | Fenerbahçe - RB Leipzig |
| Fenerbahçe - Inter | Inter - Arsenal |
| Manchester United - Spartak | Manchester United - Aberdeen |
| Real Betis - Milan | Newcastle United - Spartak |
| Roma - VfB Stuttgart | Rangers - Valencia |
| Sevilla - RB Leipzig | Real Betis - Paris SG |
| Sporting - Rangers | Sporting - Milan |
| Tottenham Hotspur - Valencia | Tottenham Hotspur - VfB Stuttgart |
|
| Round 19 (40) | Round 20 (41) |
| Aberdeen - Newcastle United | Deportivo - FC Basel |
| Arsenal - Fenerbahçe | FC Augsburg - VfB Stuttgart |
| FC Basel - Sporting | FC Twente - Paris SG |
| Milan - FC Twente | Fenerbahçe - Spartak |
| Paris SG - FC Augsburg | Inter - Valencia |
| RB Leipzig - Real Betis | Manchester United - Sevilla |
| Roma - Manchester United | Newcastle United - Milan |
| Sevilla - Tottenham Hotspur | Rangers - Aberdeen |
| Spartak - Rangers | Real Betis - Roma |
| Valencia - Deportivo | Sporting - RB Leipzig |
| VfB Stuttgart - Inter | Tottenham Hotspur - Arsenal |
|
| Round 21 (42) |
| Aberdeen - Inter |
| Arsenal - Sporting |
| FC Basel - Manchester United |
| Milan - Rangers |
| Paris SG - Deportivo |
| RB Leipzig - FC Twente |
| Roma - Tottenham Hotspur |
| Sevilla - Real Betis |
| Spartak - FC Augsburg |
| Valencia - Newcastle United |
| VfB Stuttgart - Fenerbahçe |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Deportivo - Paris SG, FC Augsburg - Spartak etc. |