| Round 1 (22) | Round 2 (23) |
| AEK - Grêmio | Anderlecht - Espanyol |
| Auxerre - Celtic | Atalanta - Fiorentina |
| Dundee United - Benfica | Athletic Bilbao - AEK |
| Espanyol - Atlético Madrid | Atlético Madrid - Real Sociedad |
| Fiorentina - Lille | B.Mönchengladbach - Parma |
| Lokomotiv - Athletic Bilbao | Benfica - Sassuolo |
| Parma - Everton | Celtic - Zenit |
| Real Sociedad - Anderlecht | Everton - Lokomotiv |
| Sassuolo - Villarreal | Grêmio - Dundee United |
| VfL Wolfsburg - B.Mönchengladbach | Lille - Auxerre |
| Zenit - Atalanta | Villarreal - VfL Wolfsburg |
|
| Round 3 (24) | Round 4 (25) |
| AEK - Lille | Anderlecht - Sassuolo |
| Auxerre - Anderlecht | Atalanta - Auxerre |
| Dundee United - Atlético Madrid | Athletic Bilbao - Fiorentina |
| Espanyol - Atalanta | Atlético Madrid - Zenit |
| Fiorentina - B.Mönchengladbach | B.Mönchengladbach - Dundee United |
| Lokomotiv - Celtic | Benfica - Lokomotiv |
| Parma - Villarreal | Celtic - Real Sociedad |
| Real Sociedad - Everton | Everton - Espanyol |
| Sassuolo - Grêmio | Grêmio - Parma |
| VfL Wolfsburg - Benfica | Lille - VfL Wolfsburg |
| Zenit - Athletic Bilbao | Villarreal - AEK |
|
| Round 5 (26) | Round 6 (27) |
| AEK - Anderlecht | AEK - Lokomotiv |
| Auxerre - Grêmio | Atalanta - Atlético Madrid |
| Dundee United - Atalanta | Athletic Bilbao - Lille |
| Espanyol - Athletic Bilbao | Auxerre - Espanyol |
| Fiorentina - Villarreal | Benfica - B.Mönchengladbach |
| Lokomotiv - B.Mönchengladbach | Dundee United - Anderlecht |
| Parma - Benfica | Everton - Celtic |
| Real Sociedad - Lille | Fiorentina - Parma |
| Sassuolo - Celtic | Real Sociedad - Zenit |
| VfL Wolfsburg - Atlético Madrid | VfL Wolfsburg - Sassuolo |
| Zenit - Everton | Villarreal - Grêmio |
|
| Round 7 (28) | Round 8 (29) |
| Anderlecht - Atalanta | AEK - VfL Wolfsburg |
| Atlético Madrid - Athletic Bilbao | Atalanta - B.Mönchengladbach |
| B.Mönchengladbach - Villarreal | Atlético Madrid - Anderlecht |
| Celtic - Dundee United | Benfica - Villarreal |
| Espanyol - Real Sociedad | Celtic - Lille |
| Grêmio - Benfica | Dundee United - Sassuolo |
| Lille - Everton | Espanyol - Parma |
| Lokomotiv - VfL Wolfsburg | Everton - Athletic Bilbao |
| Parma - AEK | Grêmio - Zenit |
| Sassuolo - Fiorentina | Lokomotiv - Fiorentina |
| Zenit - Auxerre | Real Sociedad - Auxerre |
|
| Round 9 (30) | Round 10 (31) |
| Anderlecht - Benfica | Anderlecht - Parma |
| Athletic Bilbao - Celtic | Atalanta - Benfica |
| Auxerre - Everton | Athletic Bilbao - Sassuolo |
| B.Mönchengladbach - Grêmio | Atlético Madrid - Villarreal |
| Fiorentina - AEK | Auxerre - Fiorentina |
| Lille - Atlético Madrid | Celtic - Grêmio |
| Parma - Lokomotiv | Espanyol - VfL Wolfsburg |
| Sassuolo - Real Sociedad | Everton - Dundee United |
| VfL Wolfsburg - Dundee United | Lille - B.Mönchengladbach |
| Villarreal - Atalanta | Real Sociedad - Lokomotiv |
| Zenit - Espanyol | Zenit - AEK |
|
| Round 11 (32) | Round 12 (33) |
| AEK - Atalanta | AEK - Auxerre |
| B.Mönchengladbach - Athletic Bilbao | B.Mönchengladbach - Everton |
| Benfica - Real Sociedad | Benfica - Espanyol |
| Dundee United - Espanyol | Dundee United - Athletic Bilbao |
| Fiorentina - Zenit | Fiorentina - Real Sociedad |
| Grêmio - Atlético Madrid | Grêmio - Lille |
| Lokomotiv - Anderlecht | Lokomotiv - Atlético Madrid |
| Parma - Auxerre | Parma - Zenit |
| Sassuolo - Everton | Sassuolo - Atalanta |
| VfL Wolfsburg - Celtic | VfL Wolfsburg - Anderlecht |
| Villarreal - Lille | Villarreal - Celtic |
|
| Round 13 (34) | Round 14 (35) |
| Anderlecht - Grêmio | AEK - Atlético Madrid |
| Atalanta - Lokomotiv | B.Mönchengladbach - Espanyol |
| Athletic Bilbao - Benfica | Benfica - Lille |
| Atlético Madrid - Fiorentina | Dundee United - Real Sociedad |
| Auxerre - VfL Wolfsburg | Fiorentina - Celtic |
| Celtic - B.Mönchengladbach | Grêmio - Everton |
| Espanyol - AEK | Lokomotiv - Zenit |
| Everton - Villarreal | Parma - Atalanta |
| Lille - Sassuolo | Sassuolo - Auxerre |
| Real Sociedad - Parma | VfL Wolfsburg - Athletic Bilbao |
| Zenit - Dundee United | Villarreal - Anderlecht |
|
| Round 15 (36) | Round 16 (37) |
| Anderlecht - B.Mönchengladbach | AEK - Celtic |
| Atalanta - Grêmio | B.Mönchengladbach - Zenit |
| Athletic Bilbao - Villarreal | Benfica - Everton |
| Atlético Madrid - Parma | Dundee United - Auxerre |
| Auxerre - Lokomotiv | Fiorentina - Anderlecht |
| Celtic - Benfica | Grêmio - Athletic Bilbao |
| Espanyol - Fiorentina | Lokomotiv - Espanyol |
| Everton - VfL Wolfsburg | Parma - Lille |
| Lille - Dundee United | Sassuolo - Atlético Madrid |
| Real Sociedad - AEK | VfL Wolfsburg - Atalanta |
| Zenit - Sassuolo | Villarreal - Real Sociedad |
|
| Round 17 (38) | Round 18 (39) |
| AEK - Everton | AEK - B.Mönchengladbach |
| Auxerre - Atlético Madrid | Anderlecht - Everton |
| Dundee United - Villarreal | Atalanta - Athletic Bilbao |
| Espanyol - Celtic | Atlético Madrid - Benfica |
| Fiorentina - Benfica | Auxerre - Villarreal |
| Lokomotiv - Lille | Espanyol - Sassuolo |
| Parma - Athletic Bilbao | Fiorentina - Dundee United |
| Real Sociedad - Atalanta | Lokomotiv - Grêmio |
| Sassuolo - B.Mönchengladbach | Parma - Celtic |
| VfL Wolfsburg - Grêmio | Real Sociedad - VfL Wolfsburg |
| Zenit - Anderlecht | Zenit - Lille |
|
| Round 19 (40) | Round 20 (41) |
| Athletic Bilbao - Anderlecht | AEK - Benfica |
| B.Mönchengladbach - Atlético Madrid | Anderlecht - Celtic |
| Benfica - Auxerre | Atalanta - Lille |
| Celtic - Atalanta | Atlético Madrid - Everton |
| Dundee United - AEK | Auxerre - Athletic Bilbao |
| Everton - Fiorentina | Espanyol - Grêmio |
| Grêmio - Real Sociedad | Fiorentina - VfL Wolfsburg |
| Lille - Espanyol | Lokomotiv - Sassuolo |
| Sassuolo - Parma | Parma - Dundee United |
| VfL Wolfsburg - Zenit | Real Sociedad - B.Mönchengladbach |
| Villarreal - Lokomotiv | Zenit - Villarreal |
|
| Round 21 (42) |
| Athletic Bilbao - Real Sociedad |
| B.Mönchengladbach - Auxerre |
| Benfica - Zenit |
| Celtic - Atlético Madrid |
| Dundee United - Lokomotiv |
| Everton - Atalanta |
| Grêmio - Fiorentina |
| Lille - Anderlecht |
| Sassuolo - AEK |
| VfL Wolfsburg - Parma |
| Villarreal - Espanyol |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is AEK - Sassuolo, Anderlecht - Lille etc. |