| Round 1 (22) | Round 2 (23) |
| AEK - FC Basel | Anderlecht - Rangers |
| Aberdeen - Athletic Bilbao | Athletic Bilbao - Udinese |
| Everton - Grêmio | Celtic - Nice |
| FC Augsburg - Leeds United | FC Basel - Everton |
| Fenerbahçe - Parma | Grêmio - AEK |
| Nice - Lazio | Lazio - Aberdeen |
| Rangers - Zenit | Leeds United - Real Sociedad |
| Real Betis - Vitória Guimarães | Parma - Real Betis |
| Real Sociedad - Celtic | Roma - Fenerbahçe |
| Udinese - Anderlecht | Vitória Guimarães - West Ham United |
| West Ham United - Roma | Zenit - FC Augsburg |
|
| Round 3 (24) | Round 4 (25) |
| AEK - Lazio | Anderlecht - Nice |
| Aberdeen - Parma | Athletic Bilbao - West Ham United |
| Everton - Vitória Guimarães | Celtic - Rangers |
| FC Augsburg - Anderlecht | FC Basel - FC Augsburg |
| Fenerbahçe - FC Basel | Grêmio - Real Betis |
| Nice - Leeds United | Lazio - Everton |
| Rangers - Grêmio | Leeds United - Udinese |
| Real Betis - Athletic Bilbao | Parma - AEK |
| Real Sociedad - Zenit | Roma - Real Sociedad |
| Udinese - Roma | Vitória Guimarães - Fenerbahçe |
| West Ham United - Celtic | Zenit - Aberdeen |
|
| Round 5 (26) | Round 6 (27) |
| AEK - Roma | AEK - Real Betis |
| Aberdeen - Celtic | Athletic Bilbao - Roma |
| Everton - Athletic Bilbao | Fenerbahçe - Everton |
| FC Augsburg - Parma | Lazio - Parma |
| Fenerbahçe - Anderlecht | Leeds United - Anderlecht |
| Nice - Zenit | Rangers - FC Basel |
| Rangers - Vitória Guimarães | Real Sociedad - FC Augsburg |
| Real Betis - Lazio | Udinese - Aberdeen |
| Real Sociedad - Grêmio | Vitória Guimarães - Grêmio |
| Udinese - FC Basel | West Ham United - Nice |
| West Ham United - Leeds United | Zenit - Celtic |
|
| Round 7 (28) | Round 8 (29) |
| Aberdeen - Real Sociedad | AEK - Fenerbahçe |
| Anderlecht - Zenit | Aberdeen - West Ham United |
| Celtic - Leeds United | Anderlecht - Real Betis |
| Everton - AEK | Everton - Nice |
| FC Augsburg - West Ham United | Grêmio - FC Basel |
| FC Basel - Vitória Guimarães | Lazio - Athletic Bilbao |
| Grêmio - Athletic Bilbao | Parma - Roma |
| Nice - Udinese | Rangers - FC Augsburg |
| Parma - Rangers | Udinese - Real Sociedad |
| Real Betis - Fenerbahçe | Vitória Guimarães - Celtic |
| Roma - Lazio | Zenit - Leeds United |
|
| Round 9 (30) | Round 10 (31) |
| Athletic Bilbao - Parma | AEK - Aberdeen |
| Celtic - Anderlecht | Athletic Bilbao - FC Augsburg |
| FC Augsburg - AEK | Everton - Real Sociedad |
| FC Basel - Zenit | FC Basel - Nice |
| Fenerbahçe - Lazio | Fenerbahçe - West Ham United |
| Leeds United - Vitória Guimarães | Grêmio - Leeds United |
| Nice - Aberdeen | Lazio - Rangers |
| Real Betis - Everton | Parma - Anderlecht |
| Real Sociedad - Rangers | Real Betis - Udinese |
| Roma - Grêmio | Roma - Celtic |
| West Ham United - Udinese | Vitória Guimarães - Zenit |
|
| Round 11 (32) | Round 12 (33) |
| Aberdeen - FC Basel | Aberdeen - Grêmio |
| Anderlecht - Grêmio | Anderlecht - Roma |
| Celtic - Athletic Bilbao | Celtic - Lazio |
| FC Augsburg - Lazio | FC Augsburg - Vitória Guimarães |
| Leeds United - Roma | Leeds United - Parma |
| Nice - Fenerbahçe | Nice - Real Betis |
| Rangers - Everton | Rangers - Athletic Bilbao |
| Real Sociedad - Parma | Real Sociedad - FC Basel |
| Udinese - Vitória Guimarães | Udinese - Fenerbahçe |
| West Ham United - Real Betis | West Ham United - AEK |
| Zenit - AEK | Zenit - Everton |
|
| Round 13 (34) | Round 14 (35) |
| AEK - Nice | Aberdeen - Real Betis |
| Athletic Bilbao - Zenit | Anderlecht - Lazio |
| Everton - Udinese | Celtic - Everton |
| FC Basel - Anderlecht | FC Augsburg - Fenerbahçe |
| Fenerbahçe - Real Sociedad | Leeds United - FC Basel |
| Grêmio - West Ham United | Nice - Vitória Guimarães |
| Lazio - Leeds United | Rangers - AEK |
| Parma - Celtic | Real Sociedad - Athletic Bilbao |
| Real Betis - Rangers | Udinese - Grêmio |
| Roma - FC Augsburg | West Ham United - Parma |
| Vitória Guimarães - Aberdeen | Zenit - Roma |
|
| Round 15 (36) | Round 16 (37) |
| AEK - Udinese | Aberdeen - Everton |
| Athletic Bilbao - Leeds United | Anderlecht - Athletic Bilbao |
| Everton - West Ham United | Celtic - Real Betis |
| FC Basel - Celtic | FC Augsburg - Grêmio |
| Fenerbahçe - Aberdeen | Leeds United - AEK |
| Grêmio - Nice | Nice - Roma |
| Lazio - Real Sociedad | Rangers - Fenerbahçe |
| Parma - Zenit | Real Sociedad - Vitória Guimarães |
| Real Betis - FC Augsburg | Udinese - Parma |
| Roma - Rangers | West Ham United - FC Basel |
| Vitória Guimarães - Anderlecht | Zenit - Lazio |
|
| Round 17 (38) | Round 18 (39) |
| AEK - Vitória Guimarães | AEK - Real Sociedad |
| Aberdeen - Roma | Aberdeen - Anderlecht |
| Everton - Parma | Everton - FC Augsburg |
| FC Augsburg - Celtic | FC Basel - Lazio |
| Fenerbahçe - Grêmio | Fenerbahçe - Leeds United |
| Nice - Athletic Bilbao | Grêmio - Zenit |
| Rangers - Leeds United | Nice - Parma |
| Real Betis - FC Basel | Real Betis - Roma |
| Real Sociedad - Anderlecht | Udinese - Celtic |
| Udinese - Lazio | Vitória Guimarães - Athletic Bilbao |
| West Ham United - Zenit | West Ham United - Rangers |
|
| Round 19 (40) | Round 20 (41) |
| Anderlecht - AEK | AEK - Celtic |
| Athletic Bilbao - FC Basel | Aberdeen - FC Augsburg |
| Celtic - Grêmio | Everton - Anderlecht |
| FC Augsburg - Nice | FC Basel - Parma |
| Lazio - West Ham United | Fenerbahçe - Athletic Bilbao |
| Leeds United - Aberdeen | Grêmio - Lazio |
| Parma - Vitória Guimarães | Nice - Rangers |
| Rangers - Udinese | Real Betis - Leeds United |
| Real Sociedad - Real Betis | Udinese - Zenit |
| Roma - Everton | Vitória Guimarães - Roma |
| Zenit - Fenerbahçe | West Ham United - Real Sociedad |
|
| Round 21 (42) |
| Anderlecht - West Ham United |
| Athletic Bilbao - AEK |
| Celtic - Fenerbahçe |
| FC Augsburg - Udinese |
| Lazio - Vitória Guimarães |
| Leeds United - Everton |
| Parma - Grêmio |
| Rangers - Aberdeen |
| Real Sociedad - Nice |
| Roma - FC Basel |
| Zenit - Real Betis |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is AEK - Athletic Bilbao, Aberdeen - Rangers etc. |