| Round 1 (22) | Round 2 (23) |
| Bayer Leverkusen - Leicester City | Atlético-MG - Chelsea |
| Borussia Dortmund - Espanyol | Blackburn Rovers - Feyenoord |
| Chelsea - West Ham United | Espanyol - Santos |
| Club Brugge - Atlético-MG | Everton - Wolves |
| Dinamo Zagreb - Valencia | Hamburger SV - Bayer Leverkusen |
| Fenerbahçe - Blackburn Rovers | Leicester City - Dinamo Zagreb |
| Feyenoord - Everton | Monaco - Borussia Dortmund |
| Lyon - Hamburger SV | Real Sociedad - Fenerbahçe |
| Santos - Sampdoria | Sampdoria - Lyon |
| Sevilla - Monaco | Valencia - Sevilla |
| Wolves - Real Sociedad | West Ham United - Club Brugge |
|
| Round 3 (24) | Round 4 (25) |
| Bayer Leverkusen - West Ham United | Atlético-MG - Dinamo Zagreb |
| Borussia Dortmund - Valencia | Blackburn Rovers - Wolves |
| Chelsea - Blackburn Rovers | Espanyol - Chelsea |
| Club Brugge - Espanyol | Everton - Sevilla |
| Dinamo Zagreb - Hamburger SV | Hamburger SV - Borussia Dortmund |
| Fenerbahçe - Sampdoria | Leicester City - Santos |
| Feyenoord - Monaco | Monaco - Bayer Leverkusen |
| Lyon - Everton | Real Sociedad - Club Brugge |
| Santos - Real Sociedad | Sampdoria - Feyenoord |
| Sevilla - Leicester City | Valencia - Lyon |
| Wolves - Atlético-MG | West Ham United - Fenerbahçe |
|
| Round 5 (26) | Round 6 (27) |
| Bayer Leverkusen - Blackburn Rovers | Bayer Leverkusen - Atlético-MG |
| Borussia Dortmund - Leicester City | Blackburn Rovers - West Ham United |
| Chelsea - Sampdoria | Club Brugge - Fenerbahçe |
| Club Brugge - Everton | Espanyol - Real Sociedad |
| Dinamo Zagreb - Real Sociedad | Feyenoord - Borussia Dortmund |
| Fenerbahçe - Espanyol | Leicester City - Monaco |
| Feyenoord - Valencia | Lyon - Santos |
| Lyon - Atlético-MG | Sampdoria - Everton |
| Santos - Monaco | Sevilla - Dinamo Zagreb |
| Sevilla - West Ham United | Valencia - Hamburger SV |
| Wolves - Hamburger SV | Wolves - Chelsea |
|
| Round 7 (28) | Round 8 (29) |
| Atlético-MG - Blackburn Rovers | Bayer Leverkusen - Dinamo Zagreb |
| Borussia Dortmund - Lyon | Blackburn Rovers - Monaco |
| Chelsea - Club Brugge | Chelsea - Borussia Dortmund |
| Dinamo Zagreb - Feyenoord | Club Brugge - Wolves |
| Everton - Espanyol | Espanyol - Sampdoria |
| Fenerbahçe - Wolves | Hamburger SV - Fenerbahçe |
| Hamburger SV - Leicester City | Leicester City - Valencia |
| Monaco - Valencia | Lyon - Sevilla |
| Real Sociedad - Bayer Leverkusen | Real Sociedad - Everton |
| Santos - Sevilla | Santos - Feyenoord |
| West Ham United - Sampdoria | West Ham United - Atlético-MG |
|
| Round 9 (30) | Round 10 (31) |
| Atlético-MG - Leicester City | Atlético-MG - Borussia Dortmund |
| Borussia Dortmund - Santos | Blackburn Rovers - Leicester City |
| Dinamo Zagreb - Club Brugge | Chelsea - Sevilla |
| Everton - West Ham United | Club Brugge - Santos |
| Fenerbahçe - Chelsea | Espanyol - Bayer Leverkusen |
| Feyenoord - Lyon | Everton - Monaco |
| Monaco - Hamburger SV | Fenerbahçe - Lyon |
| Sampdoria - Real Sociedad | Real Sociedad - Hamburger SV |
| Sevilla - Bayer Leverkusen | Sampdoria - Dinamo Zagreb |
| Valencia - Blackburn Rovers | West Ham United - Valencia |
| Wolves - Espanyol | Wolves - Feyenoord |
|
| Round 11 (32) | Round 12 (33) |
| Bayer Leverkusen - Chelsea | Bayer Leverkusen - Sampdoria |
| Borussia Dortmund - Wolves | Borussia Dortmund - Fenerbahçe |
| Dinamo Zagreb - Espanyol | Dinamo Zagreb - Blackburn Rovers |
| Feyenoord - Fenerbahçe | Feyenoord - Club Brugge |
| Hamburger SV - West Ham United | Hamburger SV - Everton |
| Leicester City - Club Brugge | Leicester City - Chelsea |
| Lyon - Blackburn Rovers | Lyon - Wolves |
| Monaco - Sampdoria | Monaco - Espanyol |
| Santos - Atlético-MG | Santos - West Ham United |
| Sevilla - Real Sociedad | Sevilla - Atlético-MG |
| Valencia - Everton | Valencia - Real Sociedad |
|
| Round 13 (34) | Round 14 (35) |
| Atlético-MG - Hamburger SV | Bayer Leverkusen - Club Brugge |
| Blackburn Rovers - Santos | Borussia Dortmund - Blackburn Rovers |
| Chelsea - Lyon | Dinamo Zagreb - Wolves |
| Club Brugge - Borussia Dortmund | Feyenoord - Real Sociedad |
| Espanyol - Valencia | Hamburger SV - Espanyol |
| Everton - Dinamo Zagreb | Leicester City - Everton |
| Fenerbahçe - Bayer Leverkusen | Lyon - West Ham United |
| Real Sociedad - Monaco | Monaco - Chelsea |
| Sampdoria - Leicester City | Santos - Fenerbahçe |
| West Ham United - Feyenoord | Sevilla - Sampdoria |
| Wolves - Sevilla | Valencia - Atlético-MG |
|
| Round 15 (36) | Round 16 (37) |
| Atlético-MG - Monaco | Bayer Leverkusen - Wolves |
| Blackburn Rovers - Hamburger SV | Borussia Dortmund - Everton |
| Chelsea - Feyenoord | Dinamo Zagreb - West Ham United |
| Club Brugge - Lyon | Feyenoord - Atlético-MG |
| Espanyol - Sevilla | Hamburger SV - Sampdoria |
| Everton - Bayer Leverkusen | Leicester City - Espanyol |
| Fenerbahçe - Dinamo Zagreb | Lyon - Real Sociedad |
| Real Sociedad - Leicester City | Monaco - Fenerbahçe |
| Sampdoria - Valencia | Santos - Chelsea |
| West Ham United - Borussia Dortmund | Sevilla - Blackburn Rovers |
| Wolves - Santos | Valencia - Club Brugge |
|
| Round 17 (38) | Round 18 (39) |
| Bayer Leverkusen - Valencia | Atlético-MG - Espanyol |
| Borussia Dortmund - Sampdoria | Blackburn Rovers - Sampdoria |
| Chelsea - Real Sociedad | Borussia Dortmund - Real Sociedad |
| Club Brugge - Blackburn Rovers | Chelsea - Dinamo Zagreb |
| Dinamo Zagreb - Monaco | Club Brugge - Sevilla |
| Fenerbahçe - Atlético-MG | Fenerbahçe - Everton |
| Feyenoord - Leicester City | Feyenoord - Bayer Leverkusen |
| Lyon - Espanyol | Lyon - Monaco |
| Santos - Everton | Santos - Hamburger SV |
| Sevilla - Hamburger SV | West Ham United - Leicester City |
| Wolves - West Ham United | Wolves - Valencia |
|
| Round 19 (40) | Round 20 (41) |
| Bayer Leverkusen - Lyon | Atlético-MG - Real Sociedad |
| Dinamo Zagreb - Borussia Dortmund | Blackburn Rovers - Everton |
| Espanyol - Feyenoord | Borussia Dortmund - Bayer Leverkusen |
| Everton - Chelsea | Chelsea - Hamburger SV |
| Hamburger SV - Club Brugge | Club Brugge - Monaco |
| Leicester City - Wolves | Fenerbahçe - Valencia |
| Monaco - West Ham United | Feyenoord - Sevilla |
| Real Sociedad - Blackburn Rovers | Lyon - Leicester City |
| Sampdoria - Atlético-MG | Santos - Dinamo Zagreb |
| Sevilla - Fenerbahçe | West Ham United - Espanyol |
| Valencia - Santos | Wolves - Sampdoria |
|
| Round 21 (42) |
| Bayer Leverkusen - Santos |
| Dinamo Zagreb - Lyon |
| Espanyol - Blackburn Rovers |
| Everton - Atlético-MG |
| Hamburger SV - Feyenoord |
| Leicester City - Fenerbahçe |
| Monaco - Wolves |
| Real Sociedad - West Ham United |
| Sampdoria - Club Brugge |
| Sevilla - Borussia Dortmund |
| Valencia - Chelsea |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Atlético-MG - Everton, Blackburn Rovers - Espanyol etc. |