| Round 1 (22) | Round 2 (23) |
| 1.FC Union Berlin - FC Porto | 1.FC Köln - 1.FC Union Berlin |
| FC Schalke 04 - Fort. Düsseldorf | Atalanta - Grêmio |
| Grêmio - Zaragoza | CSKA - Hertha BSC Berlin |
| Hansa Rostock - Leeds United | FC Porto - FC Schalke 04 |
| Hertha BSC Berlin - Vélez Sársfield | Fort. Düsseldorf - RB Leipzig |
| Lokomotiv - Tottenham Hotspur | Hearts - Udinese |
| Parma - Mallorca | Leeds United - Real Betis |
| RB Leipzig - CSKA | Mallorca - Lokomotiv |
| Rayo Vallecano - Hearts | Tottenham Hotspur - Parma |
| Real Betis - Atalanta | Vélez Sársfield - Rayo Vallecano |
| Udinese - 1.FC Köln | Zaragoza - Hansa Rostock |
|
| Round 3 (24) | Round 4 (25) |
| 1.FC Union Berlin - Hearts | 1.FC Köln - Hertha BSC Berlin |
| FC Schalke 04 - Zaragoza | Atalanta - Udinese |
| Grêmio - Mallorca | CSKA - 1.FC Union Berlin |
| Hansa Rostock - Fort. Düsseldorf | FC Porto - Lokomotiv |
| Hertha BSC Berlin - Tottenham Hotspur | Fort. Düsseldorf - Real Betis |
| Lokomotiv - Leeds United | Hearts - RB Leipzig |
| Parma - FC Porto | Leeds United - Grêmio |
| RB Leipzig - Atalanta | Mallorca - Rayo Vallecano |
| Rayo Vallecano - CSKA | Tottenham Hotspur - Hansa Rostock |
| Real Betis - 1.FC Köln | Vélez Sársfield - FC Schalke 04 |
| Udinese - Vélez Sársfield | Zaragoza - Parma |
|
| Round 5 (26) | Round 6 (27) |
| 1.FC Union Berlin - Vélez Sársfield | FC Porto - Zaragoza |
| FC Schalke 04 - 1.FC Köln | Fort. Düsseldorf - Atalanta |
| Grêmio - CSKA | Grêmio - Lokomotiv |
| Hansa Rostock - FC Porto | Hearts - CSKA |
| Hertha BSC Berlin - Leeds United | Hertha BSC Berlin - Mallorca |
| Lokomotiv - Fort. Düsseldorf | Leeds United - Tottenham Hotspur |
| Parma - Atalanta | Parma - Hansa Rostock |
| RB Leipzig - Mallorca | RB Leipzig - FC Schalke 04 |
| Rayo Vallecano - Zaragoza | Real Betis - 1.FC Union Berlin |
| Real Betis - Hearts | Udinese - Rayo Vallecano |
| Udinese - Tottenham Hotspur | Vélez Sársfield - 1.FC Köln |
|
| Round 7 (28) | Round 8 (29) |
| 1.FC Köln - Hearts | CSKA - Hansa Rostock |
| 1.FC Union Berlin - RB Leipzig | FC Porto - Fort. Düsseldorf |
| Atalanta - FC Porto | FC Schalke 04 - Real Betis |
| CSKA - Vélez Sársfield | Hertha BSC Berlin - Rayo Vallecano |
| FC Schalke 04 - Udinese | Leeds United - 1.FC Köln |
| Hansa Rostock - Grêmio | Lokomotiv - 1.FC Union Berlin |
| Lokomotiv - Parma | Parma - Grêmio |
| Mallorca - Leeds United | RB Leipzig - Udinese |
| Rayo Vallecano - Real Betis | Tottenham Hotspur - Mallorca |
| Tottenham Hotspur - Fort. Düsseldorf | Vélez Sársfield - Hearts |
| Zaragoza - Hertha BSC Berlin | Zaragoza - Atalanta |
|
| Round 9 (30) | Round 10 (31) |
| 1.FC Köln - CSKA | Atalanta - 1.FC Köln |
| 1.FC Union Berlin - FC Schalke 04 | FC Porto - Hertha BSC Berlin |
| Atalanta - Tottenham Hotspur | Fort. Düsseldorf - Rayo Vallecano |
| Fort. Düsseldorf - Zaragoza | Grêmio - Real Betis |
| Grêmio - FC Porto | Hansa Rostock - RB Leipzig |
| Hansa Rostock - Lokomotiv | Leeds United - Vélez Sársfield |
| Hearts - Leeds United | Lokomotiv - Udinese |
| Mallorca - Vélez Sársfield | Mallorca - 1.FC Union Berlin |
| Rayo Vallecano - Parma | Parma - FC Schalke 04 |
| Real Betis - RB Leipzig | Tottenham Hotspur - Hearts |
| Udinese - Hertha BSC Berlin | Zaragoza - CSKA |
|
| Round 11 (32) | Round 12 (33) |
| 1.FC Köln - Fort. Düsseldorf | 1.FC Köln - FC Porto |
| 1.FC Union Berlin - Grêmio | 1.FC Union Berlin - Hansa Rostock |
| CSKA - Tottenham Hotspur | CSKA - Atalanta |
| FC Schalke 04 - Mallorca | FC Schalke 04 - Tottenham Hotspur |
| Hearts - Atalanta | Hearts - Zaragoza |
| Hertha BSC Berlin - Lokomotiv | Hertha BSC Berlin - Fort. Düsseldorf |
| RB Leipzig - Leeds United | RB Leipzig - Grêmio |
| Rayo Vallecano - FC Porto | Rayo Vallecano - Leeds United |
| Real Betis - Hansa Rostock | Real Betis - Parma |
| Udinese - Zaragoza | Udinese - Mallorca |
| Vélez Sársfield - Parma | Vélez Sársfield - Lokomotiv |
|
| Round 13 (34) | Round 14 (35) |
| Atalanta - Rayo Vallecano | 1.FC Köln - Lokomotiv |
| FC Porto - Hearts | 1.FC Union Berlin - Leeds United |
| Fort. Düsseldorf - Vélez Sársfield | CSKA - FC Porto |
| Grêmio - Udinese | FC Schalke 04 - Hansa Rostock |
| Hansa Rostock - Hertha BSC Berlin | Hearts - Mallorca |
| Leeds United - FC Schalke 04 | Hertha BSC Berlin - Parma |
| Lokomotiv - RB Leipzig | RB Leipzig - Tottenham Hotspur |
| Mallorca - CSKA | Rayo Vallecano - Grêmio |
| Parma - 1.FC Union Berlin | Real Betis - Zaragoza |
| Tottenham Hotspur - Real Betis | Udinese - Fort. Düsseldorf |
| Zaragoza - 1.FC Köln | Vélez Sársfield - Atalanta |
|
| Round 15 (36) | Round 16 (37) |
| Atalanta - Hertha BSC Berlin | 1.FC Köln - Hansa Rostock |
| FC Porto - Udinese | 1.FC Union Berlin - Atalanta |
| Fort. Düsseldorf - Hearts | CSKA - Fort. Düsseldorf |
| Grêmio - FC Schalke 04 | FC Schalke 04 - Lokomotiv |
| Hansa Rostock - Rayo Vallecano | Hearts - Parma |
| Leeds United - CSKA | Hertha BSC Berlin - Grêmio |
| Lokomotiv - Real Betis | RB Leipzig - Zaragoza |
| Mallorca - 1.FC Köln | Rayo Vallecano - Tottenham Hotspur |
| Parma - RB Leipzig | Real Betis - Mallorca |
| Tottenham Hotspur - 1.FC Union Berlin | Udinese - Leeds United |
| Zaragoza - Vélez Sársfield | Vélez Sársfield - FC Porto |
|
| Round 17 (38) | Round 18 (39) |
| 1.FC Union Berlin - Fort. Düsseldorf | 1.FC Union Berlin - Zaragoza |
| FC Schalke 04 - Atalanta | FC Schalke 04 - CSKA |
| Grêmio - Tottenham Hotspur | Grêmio - Hearts |
| Hansa Rostock - Mallorca | Hansa Rostock - Atalanta |
| Hertha BSC Berlin - Hearts | Leeds United - Fort. Düsseldorf |
| Lokomotiv - Zaragoza | Lokomotiv - Rayo Vallecano |
| Parma - Leeds United | Mallorca - FC Porto |
| RB Leipzig - FC Porto | Parma - Udinese |
| Rayo Vallecano - 1.FC Köln | RB Leipzig - 1.FC Köln |
| Real Betis - Vélez Sársfield | Real Betis - Hertha BSC Berlin |
| Udinese - CSKA | Tottenham Hotspur - Vélez Sársfield |
|
| Round 19 (40) | Round 20 (41) |
| 1.FC Köln - Tottenham Hotspur | 1.FC Union Berlin - Hertha BSC Berlin |
| Atalanta - Lokomotiv | FC Schalke 04 - Rayo Vallecano |
| CSKA - Parma | Grêmio - Fort. Düsseldorf |
| FC Porto - Real Betis | Hansa Rostock - Hearts |
| Fort. Düsseldorf - Mallorca | Leeds United - Atalanta |
| Hearts - FC Schalke 04 | Lokomotiv - CSKA |
| Hertha BSC Berlin - RB Leipzig | Mallorca - Zaragoza |
| Rayo Vallecano - 1.FC Union Berlin | Parma - 1.FC Köln |
| Udinese - Hansa Rostock | RB Leipzig - Vélez Sársfield |
| Vélez Sársfield - Grêmio | Real Betis - Udinese |
| Zaragoza - Leeds United | Tottenham Hotspur - FC Porto |
|
| Round 21 (42) |
| 1.FC Köln - Grêmio |
| Atalanta - Mallorca |
| CSKA - Real Betis |
| FC Porto - Leeds United |
| Fort. Düsseldorf - Parma |
| Hearts - Lokomotiv |
| Hertha BSC Berlin - FC Schalke 04 |
| Rayo Vallecano - RB Leipzig |
| Udinese - 1.FC Union Berlin |
| Vélez Sársfield - Hansa Rostock |
| Zaragoza - Tottenham Hotspur |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is 1.FC Union Berlin - Udinese, FC Schalke 04 - Hertha BSC Berlin etc. |