| Round 1 (22) | Round 2 (23) |
| Bayern München - Atlético-MG | Athletic Bilbao - Torino |
| Celta Vigo - Borussia Dortmund | Atlético-MG - Independiente |
| IFK Göteborg - Rangers | Boca Juniors - Manchester City |
| Independiente - Athletic Bilbao | Borussia Dortmund - Milan |
| Leicester City - Wolves | Everton - Real Madrid |
| Manchester City - Everton | Rangers - Celta Vigo |
| Milan - TSG Hoffenheim | Sporting - Bayern München |
| Real Madrid - Valencia | TSG Hoffenheim - IFK Göteborg |
| Roma - West Ham United | Valencia - Sampdoria |
| Sampdoria - Sporting | West Ham United - Leicester City |
| Torino - Boca Juniors | Wolves - Roma |
|
| Round 3 (24) | Round 4 (25) |
| Bayern München - West Ham United | Athletic Bilbao - Sampdoria |
| Celta Vigo - Boca Juniors | Atlético-MG - Real Madrid |
| IFK Göteborg - Valencia | Boca Juniors - Bayern München |
| Independiente - Sporting | Borussia Dortmund - Torino |
| Leicester City - Everton | Everton - Roma |
| Manchester City - Athletic Bilbao | Rangers - Milan |
| Milan - Wolves | Sporting - Manchester City |
| Real Madrid - TSG Hoffenheim | TSG Hoffenheim - Leicester City |
| Roma - Rangers | Valencia - Celta Vigo |
| Sampdoria - Borussia Dortmund | West Ham United - IFK Göteborg |
| Torino - Atlético-MG | Wolves - Independiente |
|
| Round 5 (26) | Round 6 (27) |
| Bayern München - Rangers | Athletic Bilbao - Sporting |
| Celta Vigo - Athletic Bilbao | Atlético-MG - Boca Juniors |
| IFK Göteborg - Everton | Bayern München - Wolves |
| Independiente - TSG Hoffenheim | Celta Vigo - Manchester City |
| Leicester City - Borussia Dortmund | Everton - TSG Hoffenheim |
| Manchester City - Atlético-MG | Leicester City - IFK Göteborg |
| Milan - Sporting | Milan - Roma |
| Real Madrid - Boca Juniors | Rangers - West Ham United |
| Roma - Valencia | Sampdoria - Real Madrid |
| Sampdoria - Wolves | Torino - Independiente |
| Torino - West Ham United | Valencia - Borussia Dortmund |
|
| Round 7 (28) | Round 8 (29) |
| Boca Juniors - Athletic Bilbao | Atlético-MG - Athletic Bilbao |
| Borussia Dortmund - Everton | Bayern München - Independiente |
| IFK Göteborg - Milan | Everton - Valencia |
| Independiente - Celta Vigo | Leicester City - Milan |
| Manchester City - Sampdoria | Rangers - Boca Juniors |
| Real Madrid - Torino | Real Madrid - Celta Vigo |
| Roma - Leicester City | Roma - Manchester City |
| Sporting - Atlético-MG | Sampdoria - Torino |
| TSG Hoffenheim - Bayern München | Sporting - IFK Göteborg |
| West Ham United - Valencia | TSG Hoffenheim - Borussia Dortmund |
| Wolves - Rangers | West Ham United - Wolves |
|
| Round 9 (30) | Round 10 (31) |
| Athletic Bilbao - Rangers | Borussia Dortmund - Boca Juniors |
| Boca Juniors - Sporting | Everton - Bayern München |
| Borussia Dortmund - West Ham United | IFK Göteborg - Sampdoria |
| Celta Vigo - Sampdoria | Leicester City - Real Madrid |
| IFK Göteborg - Roma | Milan - Celta Vigo |
| Independiente - Leicester City | Rangers - Atlético-MG |
| Manchester City - Real Madrid | Roma - Torino |
| Milan - Everton | TSG Hoffenheim - Sporting |
| Torino - Bayern München | Valencia - Independiente |
| Valencia - TSG Hoffenheim | West Ham United - Athletic Bilbao |
| Wolves - Atlético-MG | Wolves - Manchester City |
|
| Round 11 (32) | Round 12 (33) |
| Athletic Bilbao - Borussia Dortmund | Athletic Bilbao - TSG Hoffenheim |
| Atlético-MG - Leicester City | Atlético-MG - Roma |
| Bayern München - Roma | Bayern München - Valencia |
| Boca Juniors - Valencia | Boca Juniors - Everton |
| Celta Vigo - IFK Göteborg | Celta Vigo - Leicester City |
| Independiente - Everton | Independiente - Rangers |
| Manchester City - Milan | Manchester City - IFK Göteborg |
| Real Madrid - Wolves | Real Madrid - West Ham United |
| Sampdoria - Rangers | Sampdoria - Milan |
| Sporting - West Ham United | Sporting - Borussia Dortmund |
| Torino - TSG Hoffenheim | Torino - Wolves |
|
| Round 13 (34) | Round 14 (35) |
| Borussia Dortmund - Independiente | Athletic Bilbao - Wolves |
| Everton - Athletic Bilbao | Atlético-MG - Borussia Dortmund |
| IFK Göteborg - Bayern München | Bayern München - Leicester City |
| Leicester City - Manchester City | Boca Juniors - Roma |
| Milan - Torino | Celta Vigo - TSG Hoffenheim |
| Rangers - Real Madrid | Independiente - Milan |
| Roma - Sampdoria | Manchester City - Rangers |
| TSG Hoffenheim - Boca Juniors | Real Madrid - IFK Göteborg |
| Valencia - Atlético-MG | Sampdoria - West Ham United |
| West Ham United - Celta Vigo | Sporting - Everton |
| Wolves - Sporting | Torino - Valencia |
|
| Round 15 (36) | Round 16 (37) |
| Borussia Dortmund - Bayern München | Athletic Bilbao - Leicester City |
| Everton - Torino | Atlético-MG - Everton |
| IFK Göteborg - Independiente | Bayern München - Milan |
| Leicester City - Sampdoria | Boca Juniors - IFK Göteborg |
| Milan - Real Madrid | Celta Vigo - Wolves |
| Rangers - Sporting | Independiente - West Ham United |
| Roma - Celta Vigo | Manchester City - Borussia Dortmund |
| TSG Hoffenheim - Atlético-MG | Real Madrid - Roma |
| Valencia - Athletic Bilbao | Sampdoria - TSG Hoffenheim |
| West Ham United - Manchester City | Sporting - Valencia |
| Wolves - Boca Juniors | Torino - Rangers |
|
| Round 17 (38) | Round 18 (39) |
| Bayern München - Athletic Bilbao | Celta Vigo - Bayern München |
| Celta Vigo - Atlético-MG | IFK Göteborg - Borussia Dortmund |
| IFK Göteborg - Wolves | Leicester City - Torino |
| Independiente - Boca Juniors | Manchester City - TSG Hoffenheim |
| Leicester City - Rangers | Milan - Athletic Bilbao |
| Manchester City - Valencia | Rangers - Valencia |
| Milan - West Ham United | Real Madrid - Sporting |
| Real Madrid - Borussia Dortmund | Roma - Independiente |
| Roma - TSG Hoffenheim | Sampdoria - Boca Juniors |
| Sampdoria - Everton | West Ham United - Atlético-MG |
| Torino - Sporting | Wolves - Everton |
|
| Round 19 (40) | Round 20 (41) |
| Athletic Bilbao - Real Madrid | Celta Vigo - Torino |
| Atlético-MG - Milan | IFK Göteborg - Athletic Bilbao |
| Bayern München - Sampdoria | Leicester City - Boca Juniors |
| Boca Juniors - West Ham United | Manchester City - Bayern München |
| Borussia Dortmund - Roma | Milan - Valencia |
| Everton - Celta Vigo | Rangers - Borussia Dortmund |
| Independiente - Manchester City | Real Madrid - Independiente |
| Sporting - Leicester City | Roma - Sporting |
| TSG Hoffenheim - Rangers | Sampdoria - Atlético-MG |
| Torino - IFK Göteborg | West Ham United - Everton |
| Valencia - Wolves | Wolves - TSG Hoffenheim |
|
| Round 21 (42) |
| Athletic Bilbao - Roma |
| Atlético-MG - IFK Göteborg |
| Bayern München - Real Madrid |
| Boca Juniors - Milan |
| Borussia Dortmund - Wolves |
| Everton - Rangers |
| Independiente - Sampdoria |
| Sporting - Celta Vigo |
| TSG Hoffenheim - West Ham United |
| Torino - Manchester City |
| Valencia - Leicester City |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Celta Vigo - Sporting, IFK Göteborg - Atlético-MG etc. |