| Round 1 (22) | Round 2 (23) |
| AEK - Barcelona | Anderlecht - AEK |
| Ajax - Arsenal | Arsenal - Sassuolo |
| FC Basel - Marseille | Barcelona - Newcastle United |
| Genoa - Napoli | Celtic - Genoa |
| Juventus - Osasuna | Deportivo - Juventus |
| Lazio - Deportivo | Flamengo - Lazio |
| Lens - Liverpool | Inter - FC Basel |
| Newcastle United - Flamengo | Liverpool - Shakhtar |
| Paris SG - Inter | Marseille - Paris SG |
| Sassuolo - Anderlecht | Napoli - Lens |
| Shakhtar - Celtic | Osasuna - Ajax |
|
| Round 3 (24) | Round 4 (25) |
| AEK - Liverpool | Anderlecht - Paris SG |
| Ajax - Deportivo | Arsenal - Lazio |
| FC Basel - Anderlecht | Barcelona - Genoa |
| Genoa - Arsenal | Celtic - Lens |
| Juventus - Flamengo | Deportivo - AEK |
| Lazio - Inter | Flamengo - Sassuolo |
| Lens - Marseille | Inter - Shakhtar |
| Newcastle United - Napoli | Liverpool - FC Basel |
| Paris SG - Celtic | Marseille - Juventus |
| Sassuolo - Osasuna | Napoli - Ajax |
| Shakhtar - Barcelona | Osasuna - Newcastle United |
|
| Round 5 (26) | Round 6 (27) |
| AEK - Arsenal | Ajax - Juventus |
| Ajax - Inter | Anderlecht - Liverpool |
| FC Basel - Napoli | Barcelona - Napoli |
| Genoa - Osasuna | Celtic - Inter |
| Juventus - Liverpool | Deportivo - Arsenal |
| Lazio - Celtic | FC Basel - Shakhtar |
| Lens - Flamengo | Genoa - Sassuolo |
| Newcastle United - Marseille | Lazio - Marseille |
| Paris SG - Barcelona | Lens - Paris SG |
| Sassuolo - Deportivo | Newcastle United - AEK |
| Shakhtar - Anderlecht | Osasuna - Flamengo |
|
| Round 7 (28) | Round 8 (29) |
| AEK - Ajax | AEK - Genoa |
| Arsenal - Osasuna | Anderlecht - Barcelona |
| Flamengo - Deportivo | Celtic - Arsenal |
| Inter - Barcelona | Deportivo - Osasuna |
| Juventus - Genoa | FC Basel - Lens |
| Liverpool - Lazio | Flamengo - Shakhtar |
| Marseille - Celtic | Inter - Marseille |
| Napoli - Anderlecht | Lazio - Juventus |
| Paris SG - FC Basel | Liverpool - Napoli |
| Sassuolo - Newcastle United | Newcastle United - Ajax |
| Shakhtar - Lens | Paris SG - Sassuolo |
|
| Round 9 (30) | Round 10 (31) |
| Ajax - Lazio | Anderlecht - Lazio |
| Arsenal - Flamengo | Barcelona - Juventus |
| Barcelona - Liverpool | Celtic - Deportivo |
| Genoa - Newcastle United | FC Basel - AEK |
| Juventus - FC Basel | Inter - Osasuna |
| Lens - Anderlecht | Lens - Genoa |
| Marseille - Deportivo | Liverpool - Flamengo |
| Napoli - Inter | Marseille - Sassuolo |
| Osasuna - Celtic | Napoli - Arsenal |
| Sassuolo - AEK | Paris SG - Ajax |
| Shakhtar - Paris SG | Shakhtar - Newcastle United |
|
| Round 11 (32) | Round 12 (33) |
| AEK - Marseille | AEK - Inter |
| Ajax - Liverpool | Ajax - Marseille |
| Arsenal - Barcelona | Arsenal - Anderlecht |
| Deportivo - FC Basel | Deportivo - Paris SG |
| Flamengo - Inter | Flamengo - Napoli |
| Genoa - Shakhtar | Genoa - FC Basel |
| Juventus - Anderlecht | Juventus - Celtic |
| Lazio - Paris SG | Lazio - Barcelona |
| Newcastle United - Celtic | Newcastle United - Lens |
| Osasuna - Napoli | Osasuna - Liverpool |
| Sassuolo - Lens | Sassuolo - Shakhtar |
|
| Round 13 (34) | Round 14 (35) |
| Anderlecht - Osasuna | AEK - Shakhtar |
| Barcelona - Deportivo | Ajax - Barcelona |
| Celtic - AEK | Arsenal - Paris SG |
| FC Basel - Sassuolo | Deportivo - Napoli |
| Inter - Genoa | Flamengo - Anderlecht |
| Lens - Ajax | Genoa - Liverpool |
| Liverpool - Arsenal | Juventus - Lens |
| Marseille - Flamengo | Lazio - FC Basel |
| Napoli - Juventus | Newcastle United - Inter |
| Paris SG - Newcastle United | Osasuna - Marseille |
| Shakhtar - Lazio | Sassuolo - Celtic |
|
| Round 15 (36) | Round 16 (37) |
| Anderlecht - Ajax | AEK - Paris SG |
| Barcelona - Osasuna | Ajax - Celtic |
| Celtic - Flamengo | Arsenal - Shakhtar |
| FC Basel - Newcastle United | Deportivo - Anderlecht |
| Inter - Sassuolo | Flamengo - Barcelona |
| Lens - AEK | Genoa - Marseille |
| Liverpool - Deportivo | Juventus - Inter |
| Marseille - Arsenal | Lazio - Lens |
| Napoli - Lazio | Newcastle United - Liverpool |
| Paris SG - Genoa | Osasuna - FC Basel |
| Shakhtar - Juventus | Sassuolo - Napoli |
|
| Round 17 (38) | Round 18 (39) |
| AEK - Napoli | AEK - Flamengo |
| Ajax - Flamengo | Celtic - Barcelona |
| FC Basel - Celtic | FC Basel - Ajax |
| Genoa - Deportivo | Genoa - Lazio |
| Juventus - Arsenal | Inter - Deportivo |
| Lazio - Osasuna | Lens - Osasuna |
| Lens - Inter | Marseille - Anderlecht |
| Newcastle United - Anderlecht | Newcastle United - Arsenal |
| Paris SG - Liverpool | Paris SG - Juventus |
| Sassuolo - Barcelona | Sassuolo - Liverpool |
| Shakhtar - Marseille | Shakhtar - Napoli |
|
| Round 19 (40) | Round 20 (41) |
| Ajax - Shakhtar | AEK - Juventus |
| Anderlecht - Genoa | Celtic - Napoli |
| Arsenal - Inter | FC Basel - Arsenal |
| Barcelona - Marseille | Genoa - Ajax |
| Deportivo - Lens | Inter - Anderlecht |
| Flamengo - FC Basel | Lens - Barcelona |
| Juventus - Sassuolo | Marseille - Liverpool |
| Lazio - Newcastle United | Newcastle United - Deportivo |
| Liverpool - Celtic | Paris SG - Flamengo |
| Napoli - Paris SG | Sassuolo - Lazio |
| Osasuna - AEK | Shakhtar - Osasuna |
|
| Round 21 (42) |
| Ajax - Sassuolo |
| Anderlecht - Celtic |
| Arsenal - Lens |
| Barcelona - FC Basel |
| Deportivo - Shakhtar |
| Flamengo - Genoa |
| Juventus - Newcastle United |
| Lazio - AEK |
| Liverpool - Inter |
| Napoli - Marseille |
| Osasuna - Paris SG |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is AEK - Lazio, Celtic - Anderlecht etc. |