| Round 5 | | Auxerre | 2 | 30 Evanilson, 33 Arcus | | Half-time: | 2-2 | | Referee: | Sandra 7 | | Attendance: | 19,969 | | Possession: | 51%-49% | | Total shots: | 11-14 | | MoM: | Estupiñan | | TV: | highlights |
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| | (4-3-3): Pacheco 6, Arcus 7½, Estupiñan 8, Lees-Melou 6 (83 Igor Gomes 6), Kumbulla 7, Onguéné 6, Dina Ebimbe 7, Terrier 6½, Walter 7, Renato Sanches 6½, Evanilson 6½ | | São Paulo | 3 | 5og Terrier, 14 Angeliño, 46 De Jong | | 82 De Jong | | (4-3-3): Jandrei 5½, Tomiyasu 6½, Angeliño 7½, McTominay 8, Diego Carlos 7½, Matviyenko 7, Ward-Prowse 6½, Kakuta 6, De Jong 7, Adams 6½, Helinho 6 | | FC Utrecht | 4 | 1 Kramer, 19 Kramer, 73 Warmerdam, 82 Kerk | | Half-time: | 2-0 | | Referee: | Beeby 8 | | Attendance: | 23,735 | | Possession: | 50%-50% | | Total shots: | 18-15 | | MoM: | Paes |
| | 24 Hoogma | | (4-3-3): Paes 8, Van Beek 7, Smal 8, Warmerdam 8, St. Jago 6½, Hoogma 6, Toornstra 6½, Kerk 7, Kramer 6½, Boussaid 7½, Simons 6½ | | Espanyol | 0 |
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| | (4-3-3): Oier 7, Miguelón 6½ (52 Vargas 6), Berchiche 7½, Marc Roca 6, David López 6, Tárrega 6, Jofre 6½, Becker 6½, Calleri 7, Melendo 6½, Javi Puado 6 | | Hajduk Split | 2 | 56 Joselu, 62 Chakvetadze | | Half-time: | 0-0 | | Referee: | Piraux 6½ | | Attendance: | 44,245 | | Possession: | 51%-49% | | Total shots: | 16-14 | | MoM: | Juranovic | | TV: | live |
| | 90+1 Juranovic | | (4-3-3): Kotarski 7, Juranovic 8, Barisic 7, Jradi 6½, Sutalo 7½, Bondar 6½ (90+4 Besirevic 6), Soticek 7, Chakvetadze 6½, Joselu 6 (90+4 Barry 6), Kenedy 6, Ivanovski 7 | | Hertha BSC Berlin | 2 | 89og Soticek, 90+3 Lazaro |
| | (4-3-3): Ospina 5½, Süle 6½, Lazaro 7, Duda 7, Stark 6½, Rekik 6, Wind 5½, Tolga 6½, Selke 7, Serdar 6½, Undav 6½ | | Lazio | 2 | 53 Dia, 77 Zaccagni | | Half-time: | 0-0 | | Referee: | Penicka 6 | | Attendance: | 34,444 | | Possession: | 57%-43% | | Total shots: | 13-18 | | MoM: | Hysaj |
| | 18 Castellanos, 80 Noslin | | (4-3-3): Provedel 7, Lazzari 7½, Hysaj 7½, Rovella 7½, Patric 7, Nielsen 7½, Castellanos 6½, Zaccagni 7½, Dia 7½, Akpa-Akpro 7, Noslin 7 | | VfL Wolfsburg | 1 | 66 William |
| | (4-3-3): Bushchan 6½, Ryerson 7, William 7, Arnold 7, Schlotterbeck 6½, Lacroix 7, Gerhardt 6½, Victor Sá 7, Larsen 5½, Fraser 6, Labeau Lascary 6 | | Leeds United | 3 | 6 Gray, 13 Summerville, 87 Gray | | Half-time: | 2-1 | | Referee: | D'Urso 6½ | | Attendance: | 36,462 | | Possession: | 50%-50% | | Total shots: | 16-12 | | MoM: | Kristensen |
| | 28 Gray | | (4-3-3): Dúbravka 7, Kristensen 7½, Maatsen 5½ (79 Crew 7), Gruev 7, Sánchez 6½, Rodon 6½, Anthony 7, Gray 7, Joseph 6½, Piroe 6, Summerville 7 | | Juventus | 1 | 8 Pavoletti |
| | (4-3-3): Cragno 6, Zappa 7, Cambiaso 7, Fagioli 7, Bisseck 6½, Ely 6, Man 6½, Kostic 7, Pavoletti 7, Yildiz 6½, Adams 6 | | Lokomotiv | 3 | 12p Glushenkov, 23 Glushenkov, 40 João Mário | | Half-time: | 3-0 | | Referee: | Constantin 5½ | | Attendance: | 29,913 | | Possession: | 54%-46% | | Total shots: | 20-13 | | MoM: | João Mário |
| | 54 Zhemaletdinov, 75 Larsson | | (4-3-3): Trott 7½, Mampassi 6, Denisov 6½, Krychowiak 7½, Kvirkvelia 6½, Magkeev 6, João Mário 8, Miranchuk 7, Glushenkov 7½, Larsson 6, Zhemaletdinov 5½ | | Dinamo | 0 |
| | 12 Akinfeev | | (4-3-3): Akinfeev 7, Varela 7½, Kerkez 7, Okay 6, Balbuena 6½, Babic 6½, Mostovoy 7, Zakharyan 6½, Komlichenko 6½, Mukhin 6½, Chalov 6 | | Mallorca | 0 |
| | Half-time: | 0-0 | | Referee: | Tanner 6½ | | Attendance: | 23,130 | | Possession: | 43%-57% | | Total shots: | 15-9 | | MoM: | Álex |
| | 16 Prats | | (4-3-3): Rajkovic 7, Sastre 7, Diego Rico 7 (63 Álex 8), Prados 6½, Raillo 7, Valjent 6½, Abel Ruiz 7, Álex Berenguer 7, Budimir 7, Prats 7, Lago Junior 6 | | Lens | 0 |
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| | (4-3-3): Léo 7½, Cash 6½, Lima 7½, Loftus-Cheek 6, Todibo 7, Gradit 7, Sotoca 6½, Ikoné 7½, Omrani 6½, Lemina 6, Aubameyang 6½ | | Nice | 3 | 24 Laborde, 28 Sanson, 74 Boga | | Half-time: | 2-0 | | Referee: | Norman 7½ | | Attendance: | 36,131 | | Possession: | 53%-47% | | Total shots: | 17-14 | | MoM: | Moffi |
| | 10 Sanson, 16 Boga, 40 Bombito | | (4-3-3): Bulka 7, Ndayishimiye 7, Abdi 7½, Sanson 7, Dante 5½ (71 Abdelmonem 7), Bombito 6, Cho 7½, Boga 7½, Moffi 7½, Moukoko 6, Laborde 6½ | | Shakhtar | 0 |
| | 59 João Mário | | (4-3-3): Jaros 7½, João Mário 7½, Rúben Vinagre 7½, Florentino Luís 6, Zabarnyi 7, Tarkowski 5½, Tetê 6½, Taison 6½, Traoré 7, Barinov 6½, Colley 6 | | Olympiakos | 1 | 39 Bakambu | | Half-time: | 1-1 | | Referee: | Cesari 6½ | | Attendance: | 32,925 | | Possession: | 52%-48% | | Total shots: | 15-12 | | MoM: | El Hilali |
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| | (4-3-3): José Sá 7, El Hilali 8½, Ba 7½, Tiago Silva 7½, Semedo 6½, Cissé 6, Randjelovic 6½, Bruma 6½, Bakambu 8, Camara 6½, El Arabi 6½ | | Ferencváros | 1 | 4 Abu Fani | | 30 Rits, 33 Abu Fani | | (4-3-3): Mignolet 7, Murillo 6½, Buchanan 8, Vanaken 8½, Onyedika 6½ (69 Maïga 6½), Mechele 6, Rasmussen 6, Rits 5½, Larin 7, Abu Fani 6½, Pesic 6 | | River Plate | 0 |
| | Half-time: | 0-2 | | Referee: | Lary 7 | | Attendance: | 39,635 | | Possession: | 37%-63% | | Total shots: | 11-10 | | MoM: | Douglas |
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| | (4-3-3): Kraft 6, Martínez 6, Lucas Beraldo 7½, Allan 6½, Díaz 6, Palavecino 5½, De La Vega 7½, Garnacho 7½, Solari 6½, Borré 6, Beltrán 6½ | | Besiktas | 2 | 14 Destro, 21 Caner |
| | (4-3-3): Mert 6½, Gedson Fernandes 8, Caner 7½, Elneny 7½, Müldür 8, Isimat-Mirin 7, Douglas 8, Güven 6½, Destro 7½, Alli 7, Valencia 7½ | | Vitória Guimarães | 2 | 4 Nélson Oliveira, 26 Zé Ferreira | | Half-time: | 2-2 | | Referee: | Lepaul 10½ | | Attendance: | 29,986 | | Possession: | 49%-51% | | Total shots: | 12-13 | | MoM: | Tomás Händel |
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| | (4-3-3): Varela 5½, Sánchez 7, Matheus Reis 6½, Tomás Händel 8, Necip 6½, Borevkovic 6½, Bondarenko 6 (90+1 Miguel Magalhães 6), Meling 6½, André Silva 7, Zé Ferreira 6½, Nélson Oliveira 6½ | | BATE | 3 | 22 Nakamura, 25 Miovski, 90+1 Isla |
| | (4-3-3): Bellaarouch 5½, Isla 7½, Sakho 7, Sigur 7, Yoshida 6½, Jefté 7½, Ljajic 6½, Nakamura 6½, Miovski 7, Ebecilio 6½ (90+1 Okriashvili 6), Ueda 6½ | | Round 4 | | Lens | 5 | 3 Ikoné, 17 Lemina, 29 Lima, 35 Loftus-Cheek, 49 Gradit | | Half-time: | 4-0 | | Referee: | Meese 7 | | Attendance: | 41,049 | | Possession: | 63%-37% | | Total shots: | 29-9 | | MoM: | Lemina |
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| | (4-3-3): Léo 7, Cash 7, Lima 7, Loftus-Cheek 4½ (77 Chotard 6), Todibo 7, Gradit 7½, Sotoca 6½, Ikoné 7½, Omrani 7, Lemina 7½, Aubameyang 7½ | | Leeds United | 1 | 61 Rutter | | 4 Piroe, 11 Summerville, 18 Piroe, 23 Anthony, 75 Rutter | | (4-3-3): Dúbravka 6, Kristensen 5½, Maatsen 6½, Gruev 7, Sánchez 6½, Rodon 6, Anthony 5½, Gray 6½, Rutter 6½, Piroe 5½, Summerville 6 |
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