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| Round 1 (22) AEK - Grêmio Auxerre - Celtic Dundee United - Benfica Espanyol - Atlético Madrid Fiorentina - Lille Lokomotiv - Athletic Bilbao Parma - Everton Real Sociedad - Anderlecht Sassuolo - Villarreal VfL Wolfsburg - B.Mönchengladbach Zenit - Atalanta | Round 2 (23) Anderlecht - Espanyol Atalanta - Fiorentina Athletic Bilbao - AEK Atlético Madrid - Real Sociedad B.Mönchengladbach - Parma Benfica - Sassuolo Celtic - Zenit Everton - Lokomotiv Grêmio - Dundee United Lille - Auxerre Villarreal - VfL Wolfsburg |
| Round 3 (24) AEK - Lille Auxerre - Anderlecht Dundee United - Atlético Madrid Espanyol - Atalanta Fiorentina - B.Mönchengladbach Lokomotiv - Celtic Parma - Villarreal Real Sociedad - Everton Sassuolo - Grêmio VfL Wolfsburg - Benfica Zenit - Athletic Bilbao | Round 4 (25) Anderlecht - Sassuolo Atalanta - Auxerre Athletic Bilbao - Fiorentina Atlético Madrid - Zenit B.Mönchengladbach - Dundee United Benfica - Lokomotiv Celtic - Real Sociedad Everton - Espanyol Grêmio - Parma Lille - VfL Wolfsburg Villarreal - AEK |
| Round 5 (26) AEK - Anderlecht Auxerre - Grêmio Dundee United - Atalanta Espanyol - Athletic Bilbao Fiorentina - Villarreal Lokomotiv - B.Mönchengladbach Parma - Benfica Real Sociedad - Lille Sassuolo - Celtic VfL Wolfsburg - Atlético Madrid Zenit - Everton | Round 6 (27) AEK - Lokomotiv Atalanta - Atlético Madrid Athletic Bilbao - Lille Auxerre - Espanyol Benfica - B.Mönchengladbach Dundee United - Anderlecht Everton - Celtic Fiorentina - Parma Real Sociedad - Zenit VfL Wolfsburg - Sassuolo Villarreal - Grêmio |
| Round 7 (28) Anderlecht - Atalanta Atlético Madrid - Athletic Bilbao B.Mönchengladbach - Villarreal Celtic - Dundee United Espanyol - Real Sociedad Grêmio - Benfica Lille - Everton Lokomotiv - VfL Wolfsburg Parma - AEK Sassuolo - Fiorentina Zenit - Auxerre | Round 8 (29) AEK - VfL Wolfsburg Atalanta - B.Mönchengladbach Atlético Madrid - Anderlecht Benfica - Villarreal Celtic - Lille Dundee United - Sassuolo Espanyol - Parma Everton - Athletic Bilbao Grêmio - Zenit Lokomotiv - Fiorentina Real Sociedad - Auxerre |
| Round 9 (30) Anderlecht - Benfica Athletic Bilbao - Celtic Auxerre - Everton B.Mönchengladbach - Grêmio Fiorentina - AEK Lille - Atlético Madrid Parma - Lokomotiv Sassuolo - Real Sociedad VfL Wolfsburg - Dundee United Villarreal - Atalanta Zenit - Espanyol | Round 10 (31) Anderlecht - Parma Atalanta - Benfica Athletic Bilbao - Sassuolo Atlético Madrid - Villarreal Auxerre - Fiorentina Celtic - Grêmio Espanyol - VfL Wolfsburg Everton - Dundee United Lille - B.Mönchengladbach Real Sociedad - Lokomotiv Zenit - AEK |
| Round 11 (32) AEK - Atalanta B.Mönchengladbach - Athletic Bilbao Benfica - Real Sociedad Dundee United - Espanyol Fiorentina - Zenit Grêmio - Atlético Madrid Lokomotiv - Anderlecht Parma - Auxerre Sassuolo - Everton VfL Wolfsburg - Celtic Villarreal - Lille | Round 12 (33) AEK - Auxerre B.Mönchengladbach - Everton Benfica - Espanyol Dundee United - Athletic Bilbao Fiorentina - Real Sociedad Grêmio - Lille Lokomotiv - Atlético Madrid Parma - Zenit Sassuolo - Atalanta VfL Wolfsburg - Anderlecht Villarreal - Celtic |
| Round 13 (34) Anderlecht - Grêmio Atalanta - Lokomotiv Athletic Bilbao - Benfica Atlético Madrid - Fiorentina Auxerre - VfL Wolfsburg Celtic - B.Mönchengladbach Espanyol - AEK Everton - Villarreal Lille - Sassuolo Real Sociedad - Parma Zenit - Dundee United | Round 14 (35) AEK - Atlético Madrid B.Mönchengladbach - Espanyol Benfica - Lille Dundee United - Real Sociedad Fiorentina - Celtic Grêmio - Everton Lokomotiv - Zenit Parma - Atalanta Sassuolo - Auxerre VfL Wolfsburg - Athletic Bilbao Villarreal - Anderlecht |
| Round 15 (36) Anderlecht - B.Mönchengladbach Atalanta - Grêmio Athletic Bilbao - Villarreal Atlético Madrid - Parma Auxerre - Lokomotiv Celtic - Benfica Espanyol - Fiorentina Everton - VfL Wolfsburg Lille - Dundee United Real Sociedad - AEK Zenit - Sassuolo | Round 16 (37) AEK - Celtic B.Mönchengladbach - Zenit Benfica - Everton Dundee United - Auxerre Fiorentina - Anderlecht Grêmio - Athletic Bilbao Lokomotiv - Espanyol Parma - Lille Sassuolo - Atlético Madrid VfL Wolfsburg - Atalanta Villarreal - Real Sociedad |
| Round 17 (38) AEK - Everton Auxerre - Atlético Madrid Dundee United - Villarreal Espanyol - Celtic Fiorentina - Benfica Lokomotiv - Lille Parma - Athletic Bilbao Real Sociedad - Atalanta Sassuolo - B.Mönchengladbach VfL Wolfsburg - Grêmio Zenit - Anderlecht | Round 18 (39) AEK - B.Mönchengladbach Anderlecht - Everton Atalanta - Athletic Bilbao Atlético Madrid - Benfica Auxerre - Villarreal Espanyol - Sassuolo Fiorentina - Dundee United Lokomotiv - Grêmio Parma - Celtic Real Sociedad - VfL Wolfsburg Zenit - Lille |
| Round 19 (40) Athletic Bilbao - Anderlecht B.Mönchengladbach - Atlético Madrid Benfica - Auxerre Celtic - Atalanta Dundee United - AEK Everton - Fiorentina Grêmio - Real Sociedad Lille - Espanyol Sassuolo - Parma VfL Wolfsburg - Zenit Villarreal - Lokomotiv | Round 20 (41) AEK - Benfica Anderlecht - Celtic Atalanta - Lille Atlético Madrid - Everton Auxerre - Athletic Bilbao Espanyol - Grêmio Fiorentina - VfL Wolfsburg Lokomotiv - Sassuolo Parma - Dundee United Real Sociedad - B.Mönchengladbach Zenit - Villarreal |
| Round 21 (42) Athletic Bilbao - Real Sociedad B.Mönchengladbach - Auxerre Benfica - Zenit Celtic - Atlético Madrid Dundee United - Lokomotiv Everton - Atalanta Grêmio - Fiorentina Lille - Anderlecht Sassuolo - AEK VfL Wolfsburg - Parma Villarreal - Espanyol | |
| League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above, i.e. round 42 is AEK - Sassuolo, Anderlecht - Lille etc. | |