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| Round 1 (22) Deportivo - Milan FC Augsburg - Rangers FC Basel - VfB Stuttgart FC Twente - Inter Fenerbahçe - Aberdeen Manchester United - Valencia Real Betis - Spartak Roma - RB Leipzig Sevilla - Arsenal Sporting - Newcastle United Tottenham Hotspur - Paris SG | Round 2 (23) Aberdeen - Sporting Arsenal - Roma Inter - FC Augsburg Milan - Fenerbahçe Newcastle United - Deportivo Paris SG - Sevilla RB Leipzig - FC Basel Rangers - FC Twente Spartak - Tottenham Hotspur Valencia - Real Betis VfB Stuttgart - Manchester United |
| Round 3 (24) Deportivo - VfB Stuttgart FC Augsburg - Valencia FC Basel - Arsenal FC Twente - Newcastle United Fenerbahçe - Rangers Manchester United - RB Leipzig Real Betis - Aberdeen Roma - Paris SG Sevilla - Inter Sporting - Spartak Tottenham Hotspur - Milan | Round 4 (25) Aberdeen - FC Augsburg Arsenal - Real Betis Inter - Sporting Milan - FC Basel Newcastle United - Fenerbahçe Paris SG - Manchester United RB Leipzig - Tottenham Hotspur Rangers - Roma Spartak - Deportivo Valencia - FC Twente VfB Stuttgart - Sevilla |
| Round 5 (26) Deportivo - RB Leipzig FC Augsburg - Milan FC Basel - Inter FC Twente - Spartak Fenerbahçe - Paris SG Manchester United - Arsenal Real Betis - VfB Stuttgart Roma - Aberdeen Sevilla - Newcastle United Sporting - Valencia Tottenham Hotspur - Rangers | Round 6 (27) Arsenal - VfB Stuttgart Deportivo - Manchester United FC Augsburg - Sporting FC Basel - Roma Fenerbahçe - FC Twente Newcastle United - Inter RB Leipzig - Paris SG Sevilla - Rangers Spartak - Milan Tottenham Hotspur - Real Betis Valencia - Aberdeen |
| Round 7 (28) Aberdeen - Sevilla FC Twente - FC Augsburg Inter - Spartak Manchester United - Tottenham Hotspur Milan - Valencia Paris SG - Arsenal Rangers - Newcastle United Real Betis - FC Basel Roma - Deportivo Sporting - Fenerbahçe VfB Stuttgart - RB Leipzig | Round 8 (29) Aberdeen - Milan Arsenal - RB Leipzig FC Augsburg - Fenerbahçe FC Twente - Manchester United Inter - Rangers Newcastle United - VfB Stuttgart Paris SG - Sporting Real Betis - Deportivo Sevilla - Roma Tottenham Hotspur - FC Basel Valencia - Spartak |
| Round 9 (30) Deportivo - Tottenham Hotspur FC Basel - Sevilla Fenerbahçe - Valencia Manchester United - Real Betis Milan - Inter RB Leipzig - Newcastle United Rangers - Arsenal Roma - FC Augsburg Spartak - Aberdeen Sporting - FC Twente VfB Stuttgart - Paris SG | Round 10 (31) Aberdeen - Paris SG FC Augsburg - Real Betis FC Twente - FC Basel Fenerbahçe - Deportivo Inter - RB Leipzig Milan - VfB Stuttgart Newcastle United - Arsenal Rangers - Manchester United Spartak - Roma Sporting - Tottenham Hotspur Valencia - Sevilla |
| Round 11 (32) Arsenal - FC Augsburg Deportivo - Sporting FC Basel - Aberdeen Manchester United - Fenerbahçe Paris SG - Inter RB Leipzig - Milan Real Betis - Rangers Roma - Valencia Sevilla - FC Twente Tottenham Hotspur - Newcastle United VfB Stuttgart - Spartak | Round 12 (33) Arsenal - FC Twente Deportivo - FC Augsburg FC Basel - Rangers Manchester United - Sporting Paris SG - Milan RB Leipzig - Aberdeen Real Betis - Inter Roma - Newcastle United Sevilla - Spartak Tottenham Hotspur - Fenerbahçe VfB Stuttgart - Valencia |
| Round 13 (34) Aberdeen - VfB Stuttgart FC Augsburg - Manchester United FC Twente - Tottenham Hotspur Fenerbahçe - FC Basel Inter - Deportivo Milan - Roma Newcastle United - Real Betis Rangers - Paris SG Spartak - Arsenal Sporting - Sevilla Valencia - RB Leipzig | Round 14 (35) Arsenal - Milan Deportivo - Aberdeen FC Basel - Spartak Manchester United - Newcastle United Paris SG - Valencia RB Leipzig - Rangers Real Betis - Sporting Roma - Fenerbahçe Sevilla - FC Augsburg Tottenham Hotspur - Inter VfB Stuttgart - FC Twente |
| Round 15 (36) Aberdeen - Arsenal FC Augsburg - Tottenham Hotspur FC Twente - Deportivo Fenerbahçe - Real Betis Inter - Manchester United Milan - Sevilla Newcastle United - Paris SG Rangers - VfB Stuttgart Spartak - RB Leipzig Sporting - Roma Valencia - FC Basel | Round 16 (37) Arsenal - Valencia Deportivo - Rangers FC Basel - Newcastle United Manchester United - Milan Paris SG - Spartak RB Leipzig - FC Augsburg Real Betis - FC Twente Roma - Inter Sevilla - Fenerbahçe Tottenham Hotspur - Aberdeen VfB Stuttgart - Sporting |
| Round 17 (38) Deportivo - Arsenal FC Augsburg - Newcastle United FC Basel - Paris SG FC Twente - Aberdeen Fenerbahçe - Inter Manchester United - Spartak Real Betis - Milan Roma - VfB Stuttgart Sevilla - RB Leipzig Sporting - Rangers Tottenham Hotspur - Valencia | Round 18 (39) Deportivo - Sevilla FC Augsburg - FC Basel FC Twente - Roma Fenerbahçe - RB Leipzig Inter - Arsenal Manchester United - Aberdeen Newcastle United - Spartak Rangers - Valencia Real Betis - Paris SG Sporting - Milan Tottenham Hotspur - VfB Stuttgart |
| Round 19 (40) Aberdeen - Newcastle United Arsenal - Fenerbahçe FC Basel - Sporting Milan - FC Twente Paris SG - FC Augsburg RB Leipzig - Real Betis Roma - Manchester United Sevilla - Tottenham Hotspur Spartak - Rangers Valencia - Deportivo VfB Stuttgart - Inter | Round 20 (41) Deportivo - FC Basel FC Augsburg - VfB Stuttgart FC Twente - Paris SG Fenerbahçe - Spartak Inter - Valencia Manchester United - Sevilla Newcastle United - Milan Rangers - Aberdeen Real Betis - Roma Sporting - RB Leipzig Tottenham Hotspur - Arsenal |
| Round 21 (42) Aberdeen - Inter Arsenal - Sporting FC Basel - Manchester United Milan - Rangers Paris SG - Deportivo RB Leipzig - FC Twente Roma - Tottenham Hotspur Sevilla - Real Betis Spartak - FC Augsburg Valencia - Newcastle United VfB Stuttgart - Fenerbahçe | |
| League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above, i.e. round 42 is Deportivo - Paris SG, FC Augsburg - Spartak etc. | |