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| Round 1 (22) Arsenal - Fiorentina Aston Villa - Manchester City Atalanta - Villarreal Chelsea - B.Mönchengladbach FC Twente - Tottenham Hotspur Lille - Sevilla Napoli - Spartak RB Leipzig - VfB Stuttgart Sassuolo - FC Porto Sporting - Dundee United Torino - Valencia | Round 2 (23) B.Mönchengladbach - Arsenal Dundee United - Chelsea FC Porto - Torino Fiorentina - Sporting Manchester City - RB Leipzig Sevilla - Sassuolo Spartak - FC Twente Tottenham Hotspur - Napoli Valencia - Aston Villa VfB Stuttgart - Atalanta Villarreal - Lille |
| Round 3 (24) Arsenal - Sevilla Aston Villa - FC Porto Atalanta - Manchester City Chelsea - Spartak FC Twente - Fiorentina Lille - B.Mönchengladbach Napoli - Villarreal RB Leipzig - Valencia Sassuolo - Dundee United Sporting - VfB Stuttgart Torino - Tottenham Hotspur | Round 4 (25) B.Mönchengladbach - Napoli Dundee United - RB Leipzig FC Porto - Atalanta Fiorentina - Chelsea Manchester City - Sassuolo Sevilla - Sporting Spartak - Aston Villa Tottenham Hotspur - Arsenal Valencia - Lille VfB Stuttgart - Torino Villarreal - FC Twente |
| Round 5 (26) Arsenal - Villarreal Aston Villa - B.Mönchengladbach Atalanta - Valencia Chelsea - FC Porto FC Twente - Sevilla Lille - VfB Stuttgart Napoli - Dundee United RB Leipzig - Tottenham Hotspur Sassuolo - Spartak Sporting - Manchester City Torino - Fiorentina | Round 6 (27) Chelsea - FC Twente Fiorentina - Tottenham Hotspur Manchester City - FC Porto Napoli - Arsenal RB Leipzig - Aston Villa Sassuolo - Lille Sevilla - Dundee United Sporting - Atalanta Torino - Spartak Valencia - VfB Stuttgart Villarreal - B.Mönchengladbach |
| Round 7 (28) Arsenal - Chelsea Aston Villa - Sporting Atalanta - Sassuolo B.Mönchengladbach - Torino Dundee United - Villarreal FC Porto - Valencia FC Twente - Napoli Lille - RB Leipzig Spartak - Fiorentina Tottenham Hotspur - Sevilla VfB Stuttgart - Manchester City | Round 8 (29) B.Mönchengladbach - Dundee United FC Porto - Arsenal FC Twente - Atalanta Fiorentina - VfB Stuttgart Lille - Sporting Napoli - Chelsea Sassuolo - RB Leipzig Torino - Aston Villa Tottenham Hotspur - Spartak Valencia - Manchester City Villarreal - Sevilla |
| Round 9 (30) Arsenal - FC Twente Aston Villa - Napoli Atalanta - Lille Chelsea - Villarreal Dundee United - Tottenham Hotspur Manchester City - Fiorentina RB Leipzig - Torino Sevilla - B.Mönchengladbach Spartak - Valencia Sporting - Sassuolo VfB Stuttgart - FC Porto | Round 10 (31) Arsenal - Sassuolo B.Mönchengladbach - FC Porto Chelsea - Sporting Dundee United - VfB Stuttgart FC Twente - RB Leipzig Fiorentina - Valencia Napoli - Lille Sevilla - Aston Villa Spartak - Atalanta Tottenham Hotspur - Manchester City Villarreal - Torino |
| Round 11 (32) Aston Villa - Villarreal Atalanta - Chelsea FC Porto - Tottenham Hotspur Lille - Spartak Manchester City - Dundee United RB Leipzig - B.Mönchengladbach Sassuolo - Fiorentina Sporting - Arsenal Torino - FC Twente Valencia - Napoli VfB Stuttgart - Sevilla | Round 12 (33) Aston Villa - Fiorentina Atalanta - Arsenal FC Porto - Dundee United Lille - Tottenham Hotspur Manchester City - B.Mönchengladbach RB Leipzig - Spartak Sassuolo - Chelsea Sporting - Napoli Torino - Sevilla Valencia - FC Twente VfB Stuttgart - Villarreal |
| Round 13 (34) Arsenal - Torino B.Mönchengladbach - VfB Stuttgart Chelsea - RB Leipzig Dundee United - Aston Villa FC Twente - Sassuolo Fiorentina - Lille Napoli - Atalanta Sevilla - Valencia Spartak - FC Porto Tottenham Hotspur - Sporting Villarreal - Manchester City | Round 14 (35) Aston Villa - Chelsea Atalanta - Fiorentina FC Porto - Villarreal Lille - Arsenal Manchester City - Spartak RB Leipzig - Sevilla Sassuolo - Tottenham Hotspur Sporting - B.Mönchengladbach Torino - Napoli Valencia - Dundee United VfB Stuttgart - FC Twente |
| Round 15 (36) Arsenal - Aston Villa B.Mönchengladbach - Valencia Chelsea - Lille Dundee United - Torino FC Twente - Sporting Fiorentina - FC Porto Napoli - Sassuolo Sevilla - Manchester City Spartak - VfB Stuttgart Tottenham Hotspur - Atalanta Villarreal - RB Leipzig | Round 16 (37) Aston Villa - Tottenham Hotspur Atalanta - Dundee United FC Porto - Sevilla Lille - FC Twente Manchester City - Napoli RB Leipzig - Fiorentina Sassuolo - B.Mönchengladbach Sporting - Spartak Torino - Chelsea Valencia - Villarreal VfB Stuttgart - Arsenal |
| Round 17 (38) Arsenal - Spartak Aston Villa - VfB Stuttgart Atalanta - Sevilla Chelsea - Tottenham Hotspur FC Twente - B.Mönchengladbach Lille - Dundee United Napoli - Fiorentina RB Leipzig - FC Porto Sassuolo - Villarreal Sporting - Valencia Torino - Manchester City | Round 18 (39) Arsenal - Dundee United Atalanta - B.Mönchengladbach Chelsea - Manchester City FC Twente - Aston Villa Fiorentina - Sevilla Lille - FC Porto Napoli - RB Leipzig Sassuolo - VfB Stuttgart Spartak - Villarreal Sporting - Torino Tottenham Hotspur - Valencia |
| Round 19 (40) Aston Villa - Atalanta B.Mönchengladbach - Fiorentina Dundee United - FC Twente FC Porto - Napoli Manchester City - Lille RB Leipzig - Arsenal Sevilla - Spartak Torino - Sassuolo Valencia - Chelsea VfB Stuttgart - Tottenham Hotspur Villarreal - Sporting | Round 20 (41) Arsenal - Manchester City Atalanta - Torino Chelsea - Sevilla FC Twente - FC Porto Fiorentina - Dundee United Lille - Aston Villa Napoli - VfB Stuttgart Sassuolo - Valencia Spartak - B.Mönchengladbach Sporting - RB Leipzig Tottenham Hotspur - Villarreal |
| Round 21 (42) Aston Villa - Sassuolo B.Mönchengladbach - Tottenham Hotspur Dundee United - Spartak FC Porto - Sporting Manchester City - FC Twente RB Leipzig - Atalanta Sevilla - Napoli Torino - Lille Valencia - Arsenal VfB Stuttgart - Chelsea Villarreal - Fiorentina | |
| League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above, i.e. round 42 is Arsenal - Valencia, Atalanta - RB Leipzig etc. | |