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| Round 1 (22) Bayern München - Atlético-MG Celta Vigo - Borussia Dortmund IFK Göteborg - Rangers Independiente - Athletic Bilbao Leicester City - Wolves Manchester City - Everton Milan - TSG Hoffenheim Real Madrid - Valencia Roma - West Ham United Sampdoria - Sporting Torino - Boca Juniors | Round 2 (23) Athletic Bilbao - Torino Atlético-MG - Independiente Boca Juniors - Manchester City Borussia Dortmund - Milan Everton - Real Madrid Rangers - Celta Vigo Sporting - Bayern München TSG Hoffenheim - IFK Göteborg Valencia - Sampdoria West Ham United - Leicester City Wolves - Roma |
| Round 3 (24) Bayern München - West Ham United Celta Vigo - Boca Juniors IFK Göteborg - Valencia Independiente - Sporting Leicester City - Everton Manchester City - Athletic Bilbao Milan - Wolves Real Madrid - TSG Hoffenheim Roma - Rangers Sampdoria - Borussia Dortmund Torino - Atlético-MG | Round 4 (25) Athletic Bilbao - Sampdoria Atlético-MG - Real Madrid Boca Juniors - Bayern München Borussia Dortmund - Torino Everton - Roma Rangers - Milan Sporting - Manchester City TSG Hoffenheim - Leicester City Valencia - Celta Vigo West Ham United - IFK Göteborg Wolves - Independiente |
| Round 5 (26) Bayern München - Rangers Celta Vigo - Athletic Bilbao IFK Göteborg - Everton Independiente - TSG Hoffenheim Leicester City - Borussia Dortmund Manchester City - Atlético-MG Milan - Sporting Real Madrid - Boca Juniors Roma - Valencia Sampdoria - Wolves Torino - West Ham United | Round 6 (27) Athletic Bilbao - Sporting Atlético-MG - Boca Juniors Bayern München - Wolves Celta Vigo - Manchester City Everton - TSG Hoffenheim Leicester City - IFK Göteborg Milan - Roma Rangers - West Ham United Sampdoria - Real Madrid Torino - Independiente Valencia - Borussia Dortmund |
| Round 7 (28) Boca Juniors - Athletic Bilbao Borussia Dortmund - Everton IFK Göteborg - Milan Independiente - Celta Vigo Manchester City - Sampdoria Real Madrid - Torino Roma - Leicester City Sporting - Atlético-MG TSG Hoffenheim - Bayern München West Ham United - Valencia Wolves - Rangers | Round 8 (29) Atlético-MG - Athletic Bilbao Bayern München - Independiente Everton - Valencia Leicester City - Milan Rangers - Boca Juniors Real Madrid - Celta Vigo Roma - Manchester City Sampdoria - Torino Sporting - IFK Göteborg TSG Hoffenheim - Borussia Dortmund West Ham United - Wolves |
| Round 9 (30) Athletic Bilbao - Rangers Boca Juniors - Sporting Borussia Dortmund - West Ham United Celta Vigo - Sampdoria IFK Göteborg - Roma Independiente - Leicester City Manchester City - Real Madrid Milan - Everton Torino - Bayern München Valencia - TSG Hoffenheim Wolves - Atlético-MG | Round 10 (31) Borussia Dortmund - Boca Juniors Everton - Bayern München IFK Göteborg - Sampdoria Leicester City - Real Madrid Milan - Celta Vigo Rangers - Atlético-MG Roma - Torino TSG Hoffenheim - Sporting Valencia - Independiente West Ham United - Athletic Bilbao Wolves - Manchester City |
| Round 11 (32) Athletic Bilbao - Borussia Dortmund Atlético-MG - Leicester City Bayern München - Roma Boca Juniors - Valencia Celta Vigo - IFK Göteborg Independiente - Everton Manchester City - Milan Real Madrid - Wolves Sampdoria - Rangers Sporting - West Ham United Torino - TSG Hoffenheim | Round 12 (33) Athletic Bilbao - TSG Hoffenheim Atlético-MG - Roma Bayern München - Valencia Boca Juniors - Everton Celta Vigo - Leicester City Independiente - Rangers Manchester City - IFK Göteborg Real Madrid - West Ham United Sampdoria - Milan Sporting - Borussia Dortmund Torino - Wolves |
| Round 13 (34) Borussia Dortmund - Independiente Everton - Athletic Bilbao IFK Göteborg - Bayern München Leicester City - Manchester City Milan - Torino Rangers - Real Madrid Roma - Sampdoria TSG Hoffenheim - Boca Juniors Valencia - Atlético-MG West Ham United - Celta Vigo Wolves - Sporting | Round 14 (35) Athletic Bilbao - Wolves Atlético-MG - Borussia Dortmund Bayern München - Leicester City Boca Juniors - Roma Celta Vigo - TSG Hoffenheim Independiente - Milan Manchester City - Rangers Real Madrid - IFK Göteborg Sampdoria - West Ham United Sporting - Everton Torino - Valencia |
| Round 15 (36) Borussia Dortmund - Bayern München Everton - Torino IFK Göteborg - Independiente Leicester City - Sampdoria Milan - Real Madrid Rangers - Sporting Roma - Celta Vigo TSG Hoffenheim - Atlético-MG Valencia - Athletic Bilbao West Ham United - Manchester City Wolves - Boca Juniors | Round 16 (37) Athletic Bilbao - Leicester City Atlético-MG - Everton Bayern München - Milan Boca Juniors - IFK Göteborg Celta Vigo - Wolves Independiente - West Ham United Manchester City - Borussia Dortmund Real Madrid - Roma Sampdoria - TSG Hoffenheim Sporting - Valencia Torino - Rangers |
| Round 17 (38) Bayern München - Athletic Bilbao Celta Vigo - Atlético-MG IFK Göteborg - Wolves Independiente - Boca Juniors Leicester City - Rangers Manchester City - Valencia Milan - West Ham United Real Madrid - Borussia Dortmund Roma - TSG Hoffenheim Sampdoria - Everton Torino - Sporting | Round 18 (39) Celta Vigo - Bayern München IFK Göteborg - Borussia Dortmund Leicester City - Torino Manchester City - TSG Hoffenheim Milan - Athletic Bilbao Rangers - Valencia Real Madrid - Sporting Roma - Independiente Sampdoria - Boca Juniors West Ham United - Atlético-MG Wolves - Everton |
| Round 19 (40) Athletic Bilbao - Real Madrid Atlético-MG - Milan Bayern München - Sampdoria Boca Juniors - West Ham United Borussia Dortmund - Roma Everton - Celta Vigo Independiente - Manchester City Sporting - Leicester City TSG Hoffenheim - Rangers Torino - IFK Göteborg Valencia - Wolves | Round 20 (41) Celta Vigo - Torino IFK Göteborg - Athletic Bilbao Leicester City - Boca Juniors Manchester City - Bayern München Milan - Valencia Rangers - Borussia Dortmund Real Madrid - Independiente Roma - Sporting Sampdoria - Atlético-MG West Ham United - Everton Wolves - TSG Hoffenheim |
| Round 21 (42) Athletic Bilbao - Roma Atlético-MG - IFK Göteborg Bayern München - Real Madrid Boca Juniors - Milan Borussia Dortmund - Wolves Everton - Rangers Independiente - Sampdoria Sporting - Celta Vigo TSG Hoffenheim - West Ham United Torino - Manchester City Valencia - Leicester City | |
| League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above, i.e. round 42 is Celta Vigo - Sporting, IFK Göteborg - Atlético-MG etc. | |